CpG Methylation patterns in the IFN promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non-atopics

CpG Methylation patterns in the IFN promoter in naive T cells: Variations during Th1 and Th2 differentiation and between atopics and non-atopics

Interferon- (IFN) gene expression is tightly regulated in early life, and exaggerated negative control of IFN production in CD4+ T cells has been associated with risk for subsequent development of atopy. Recent studies have demonstrated hypermethylation of CpG sites in the IFN promoter in neonates,...

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Bibliographic Details
Main Authors: White, Greg, Hollams, E., Yerkovich, S., Bosco, A., Holt, B., Bassami, M., Kusel, M., Sly, P., Holt, P.
Format: Journal Article
Published: Blackwell Publishing 2006
Online Access:http://hdl.handle.net/20.500.11937/7829

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