MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/ T-cell lymphoma

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MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/ T-cell lymphoma

Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we exam...

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Bibliographic Details
Main Authors:	Li, B., Yan, J., Phyu, T., Fan, S., Chung, T.H., Mustafa, N., Lin, B., Wang, L., Eichhorn, Pieter, Goh, B.C., Ng, S.B., Kappei, D., Chng, W.J.
Format:	Journal Article
Language:	English
Published:	AMER SOC HEMATOLOGY 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Hematology T-CELL CANCER PROLIFERATION BORTEZOMIB RESISTANCE OVEREXPRESSION UBIQUITINATION MULTICENTER METHYLATION COMBINATION
Online Access:	http://hdl.handle.net/20.500.11937/77889

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