MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/ T-cell lymphoma

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/ T-cell lymphoma

Oncogenic EZH2 is overexpressed and extensively involved in the pathophysiology of different cancers including extranodal natural killer/T-cell lymphoma (NKTL). However, the mechanisms regarding EZH2 upregulation is poorly understood, and it still remains untargetable in NKTL. In this study, we exam...

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Bibliographic Details
Main Authors: Li, B., Yan, J., Phyu, T., Fan, S., Chung, T.H., Mustafa, N., Lin, B., Wang, L., Eichhorn, Pieter, Goh, B.C., Ng, S.B., Kappei, D., Chng, W.J.
Format: Journal Article
Language:English
Published: AMER SOC HEMATOLOGY 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Hematology
T-CELL
CANCER
PROLIFERATION
BORTEZOMIB
RESISTANCE
OVEREXPRESSION
UBIQUITINATION
MULTICENTER
METHYLATION
COMBINATION
Online Access:http://hdl.handle.net/20.500.11937/77889

Internet

http://hdl.handle.net/20.500.11937/77889

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