Novel pH-responsive dextrin nanogels for doxorubicin delivery to cancer cells with reduced cytotoxicity to cardiomyocytes and stem cells

Novel pH-responsive dextrin nanogels for doxorubicin delivery to cancer cells with reduced cytotoxicity to cardiomyocytes and stem cells

The aim of this study was to develop pH-responsive dextrin nanogels (DNGs) capable of triggered intracellular DOX release at the lower pH of cancer cells. DNGs were prepared by an emulsion cross-linking method using glyoxal as cross-linker to create an acid-labile bond. A higher molecular weight of...

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Bibliographic Details
Main Authors: Manchun, S., Cheewatanakornkool, K., Dass, Crispin, Sriamornsak, P.
Format: Journal Article
Published: Elsevier 2014
Subjects:
Nanogels
Dextrin
pH-responsive
Cancer
Doxorubicin
Online Access:http://hdl.handle.net/20.500.11937/7733

Internet

http://hdl.handle.net/20.500.11937/7733

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