Desferrithiocin is a more potent antineoplastic agent than desferrioxamine

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Desferrithiocin is a more potent antineoplastic agent than desferrioxamine

Desferrithiocin (DFT) is an orally effective Fe chelator, with a similar high affinity and selectivity for Fe to desferrioxamine (DFO), which has been shown clinically to possess antineoplastic activity. In this study, DFT was assessed for antineoplastic potential in hepatocellular carcinoma cell li...

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Bibliographic Details
Main Authors:	Kicic, Anthony, Chua, A.C.G., Baker, E.
Format:	Journal Article
Language:	English
Published:	NATURE PUBLISHING GROUP 2002
Subjects:	Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy desferrithiocin desferrioxamine Fe chelators Fe uptake hepatocellular carcinoma EFFECTIVE ANTIPROLIFERATIVE AGENTS ISONICOTINOYL HYDRAZONE CLASS NEUROBLASTOMA CELL-LINES IRON CHELATORS ANTINEUROBLASTOMA ACTIVITY HEPATOCELLULAR-CARCINOMA TRANSFERRIN UPTAKE CYTO-TOXICITY TUMOR-CELLS D-CECAT
Online Access:	http://hdl.handle.net/20.500.11937/76835

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