Desferrithiocin is a more potent antineoplastic agent than desferrioxamine

Desferrithiocin is a more potent antineoplastic agent than desferrioxamine

Desferrithiocin (DFT) is an orally effective Fe chelator, with a similar high affinity and selectivity for Fe to desferrioxamine (DFO), which has been shown clinically to possess antineoplastic activity. In this study, DFT was assessed for antineoplastic potential in hepatocellular carcinoma cell li...

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Bibliographic Details
Main Authors: Kicic, Anthony, Chua, A.C.G., Baker, E.
Format: Journal Article
Language:English
Published: NATURE PUBLISHING GROUP 2002
Subjects:
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
desferrithiocin
desferrioxamine
Fe chelators
Fe uptake
hepatocellular carcinoma
EFFECTIVE ANTIPROLIFERATIVE AGENTS
ISONICOTINOYL HYDRAZONE CLASS
NEUROBLASTOMA CELL-LINES
IRON CHELATORS
ANTINEUROBLASTOMA ACTIVITY
HEPATOCELLULAR-CARCINOMA
TRANSFERRIN UPTAKE
CYTO-TOXICITY
TUMOR-CELLS
D-CECAT
Online Access:http://hdl.handle.net/20.500.11937/76835

Internet

http://hdl.handle.net/20.500.11937/76835

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