The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents

QR Code

The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents

Iron (Fe) is essential for the proliferation of cancer cells. A subgroup of the orthosubstituted phenolate class of Fe chelators, desferrithiocin [2-(3′-hydroxypyrid-2′-yl)-4-methyl- Δ2-thiazoline-4(S)-carboxylic acid; DFT] and its analogues, have potential application in short-term chemotherapy for...

Full description

Bibliographic Details
Main Authors:	Kicic, Anthony, Chua, A.C.G., Baker, E.
Format:	Journal Article
Language:	English
Published:	OXFORD UNIV PRESS 2001
Subjects:	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Oncology Chemistry, Medicinal Pharmacology & Pharmacy cancer desferrioxamine desferrithiocin Fe chelators fetal and adult derived hepatoma cells PYRIDOXAL ISONICOTINOYL HYDRAZONE EFFECTIVE ANTIPROLIFERATIVE AGENTS HUMAN NEUROBLASTOMA CELL MALIGNANT MELANOMA CELL TRANSFERRIN RECEPTOR MONOCLONAL-ANTIBODY IRON(III) CHELATOR DNA-SYNTHESIS HL-60 CELLS DESFERRIOXAMINE
Online Access:	http://hdl.handle.net/20.500.11937/76831

Similar Items

Desferrithiocin is a more potent antineoplastic agent than desferrioxamine
by: Kicic, Anthony, et al.
Published: (2002)

Effect of iron chelators on proliferation and iron uptake in hepatoma cells
by: Kicic, Anthony, et al.
Published: (2001)

Influence of chelating agents on structural, optical, and electromgnetic interference properties of copper selenide nanoparticles synthesized via microwave-assisted method
by: Garba, Shitu Ibrahim
Published: (2021)

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial
by: Patel, Poulam M., et al.
Published: (2018)

The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health
by: Horniblow, Richard D., et al.
Published: (2016)

Iron chelates: a challenge to chemists and Mössbauer spectroscopists
by: Homonnay, Z., et al.
Published: (2008)

Penghasilan Sel Hibridoma Menggunakan Teknik Elektrofusion
by: Hamid, Muhajir
Published: (1995)

Malignant inflammation in cutaneous T-cell lymphoma: a hostile takeover
by: Krejsgaard, Thorbjørn, et al.
Published: (2016)

Long-term topical corticosteroid use and risk of skin cancer: a systematic review protocol
by: Ratib, Sonia, et al.
Published: (2016)

Effects of mild gestational diabetes mellitus on quality of umbilical cord blood hematopoietic stem cells procured at delivery
by: Ahmed, Sara. M.El.
Published: (2018)

Suppression of apoptosis in perfusion culture of Myeloma NS0 cells enhances cell growth but reduces antibody productivity
by: Tey, Beng Ti, et al.
Published: (2004)

Cellular and molecular mechanisms underlying extravasation of human Wharton’s jelly mesenchymal stem cells across fetal and adult endothelial cell monolayers
by: Ebrahim, Neven
Published: (2016)

Anticancer effects of combined gamma-tocotrienol and 13-cis retinoic acid against neuroblastoma cells and xenografts
by: Ch'ng, Qin Ting
Published: (2021)

Survival from uveal melanoma in Western Australia 1981–2005
by: Chew, A., et al.
Published: (2015)

Suppression Effect of Eurycomanone on the Growth of Human Hepatoma Cells (Hepg2) by Inducing P53-Mediated Apoptotic Pathway
by: Zakaria, Yusmazura
Published: (2009)

Establishment of conditional Wnt5a transgenic embryonic stem cell line and its application during neural differentiation process
by: Mohamed Hisham, Nurul Afiqah
Published: (2017)

Glucose uptake mechanism of muscle cells and adipocytes stimulated by Scoparia dulcis linn extract
by: Beh, Joo Ee
Published: (2011)

Effects of omentin on endothelial disruption and hydrogen peroxide-induced inflammation in vascular endothelial cell monolayer
by: Kamaruddin, Nur Aqilah
Published: (2022)

Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015)

Generation, propagation and characterization of second and full-term amniotic fluid-derived mesenchymal stem cell
by: Ghoraishizadeh, Peyman
Published: (2016)

The influence of stromal fibroblast on antigen-presenting cell function and alteration of their biology
by: Mohammad, Salaheddin
Published: (2022)

Dietary supplementation with ferric tyrosine improves zootechnical performance and reduces caecal Campylobacter spp. load in poultry
by: Currie, D., et al.
Published: (2018)

Improving the mesodermal differentiation potential of human embryonic stem cells
by: Burridge, Paul Wesley
Published: (2008)

Human rather than mouse mesenchymal stem cells in 3D co-culture models boost proliferative and migratory characteristics of colorectal cancer cells through paracrine signalling pathways, highlighting species disconnects
by: Lu, M.
Published: (2022)

Activation of Survival and Apoptotic Signaling Pathways in Lymphocytes Exposed to Palmitic Acid
by: Takahashi, H., et al.
Published: (2011)

Investigating the existence of neural stem cells in the adult mouse cerebellum and third ventricle
by: Salih, Shelanah
Published: (2016)

The impact of stroma and ionising radiation on the plasticity of dendritic cells and macrophages
by: Malecka, Anna A.
Published: (2018)

A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays
by: Patel, Asha K., et al.
Published: (2015)

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
by: Sampaziotis, Fotios, et al.
Published: (2017)

Development of biomimetic platforms to investigate the influence of the extra-cellular environment on immunological responses
by: Donaldson, Amy Rose
Published: (2017)

Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges
by: Amer, Mahetab H., et al.
Published: (2017)

A biomaterials approach to influence stem cell fate in injectable cell-based therapies
by: Amer, Mahetab H., et al.
Published: (2018)

Human mesenchymal stromal cells modulate T-cell immune response via transcriptomic regulation
by: Vellasamy, Shalini, et al.
Published: (2016)

Characterisation of human bronchial epithelial response to injury and identification of potential resident progenitor cells in vitro
by: Nijmeh, Hala S.
Published: (2009)

Materials for stem cell factories of the future
by: Celiz, Adam D., et al.
Published: (2014)

Chemically diverse polyacrylate and polyacrylamide surfaces for human cardiomyocyte culture and their effect on phenotype
by: Patel, Asha K.
Published: (2014)

An objective comparison of cell-tracking algorithms
by: Ulman, Vladimír, et al.
Published: (2017)

Investigating the Mechanism of Action of Antitumour Benzoprims
by: Hatfield, Amelia
Published: (2024)

The role of calcium activated and voltage gated potassium channel BK, in glioblastoma multiforme membrane potential.
by: Ratnasingham, Mathuscha
Published: (2024)

Effect of Bcl-2 overexpression on cell cycle and antibody productivity in chemostat cultures of myeloma NS0 cells
by: Tey, Beng Ti, et al.
Published: (2005)

Cannot write session to /tmp/vufind_sessions/sess_55iv5lqb99mm23bu4i69u2hbds