The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents

The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents

Iron (Fe) is essential for the proliferation of cancer cells. A subgroup of the orthosubstituted phenolate class of Fe chelators, desferrithiocin [2-(3′-hydroxypyrid-2′-yl)-4-methyl- Δ2-thiazoline-4(S)-carboxylic acid; DFT] and its analogues, have potential application in short-term chemotherapy for...

Full description

Bibliographic Details
Main Authors: Kicic, Anthony, Chua, A.C.G., Baker, E.
Format: Journal Article
Language:English
Published: OXFORD UNIV PRESS 2001
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Oncology
Chemistry, Medicinal
Pharmacology & Pharmacy
cancer
desferrioxamine
desferrithiocin
Fe chelators
fetal and adult derived hepatoma cells
PYRIDOXAL ISONICOTINOYL HYDRAZONE
EFFECTIVE ANTIPROLIFERATIVE AGENTS
HUMAN NEUROBLASTOMA CELL
MALIGNANT MELANOMA CELL
TRANSFERRIN RECEPTOR
MONOCLONAL-ANTIBODY
IRON(III) CHELATOR
DNA-SYNTHESIS
HL-60 CELLS
DESFERRIOXAMINE
Online Access:http://hdl.handle.net/20.500.11937/76831

Internet

http://hdl.handle.net/20.500.11937/76831

Similar Items