Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1

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Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1

Rationale: Airway remodeling in asthma is associated with the accumulation of fibroblasts, the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal tr...

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Bibliographic Details
Main Authors:	Hackett, T.L., Warner, S.M., Stefanowicz, D., Shaheen, F., Pechkovsky, D.V., Murray, L.A., Argentieri, R., Kicic, Anthony, Stick, S.M., Bai, T.R., Knight, D.A.
Format:	Journal Article
Language:	English
Published:	AMER THORACIC SOC 2009
Subjects:	Science & Technology Life Sciences & Biomedicine Critical Care Medicine Respiratory System General & Internal Medicine asthma epithelial-mesenchymal transition transforming growth factor-beta 1 epithelium GROWTH-FACTOR-BETA RETICULAR BASEMENT-MEMBRANE ACTIVATED PROTEIN-KINASE PULMONARY-FIBROSIS EXPRESSION MOUSE LUNG SMAD TRANSDIFFERENTIATION TGF-BETA-1
Online Access:	http://hdl.handle.net/20.500.11937/76819

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