Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1

Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-β1

Rationale: Airway remodeling in asthma is associated with the accumulation of fibroblasts, the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal tr...

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Bibliographic Details
Main Authors: Hackett, T.L., Warner, S.M., Stefanowicz, D., Shaheen, F., Pechkovsky, D.V., Murray, L.A., Argentieri, R., Kicic, Anthony, Stick, S.M., Bai, T.R., Knight, D.A.
Format: Journal Article
Language:English
Published: AMER THORACIC SOC 2009
Subjects:
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
asthma
epithelial-mesenchymal transition
transforming growth factor-beta 1
epithelium
GROWTH-FACTOR-BETA
RETICULAR BASEMENT-MEMBRANE
ACTIVATED PROTEIN-KINASE
PULMONARY-FIBROSIS
EXPRESSION
MOUSE
LUNG
SMAD
TRANSDIFFERENTIATION
TGF-BETA-1
Online Access:http://hdl.handle.net/20.500.11937/76819

Internet

http://hdl.handle.net/20.500.11937/76819

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