Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium

Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium

Rationale: Damage to airway epitheliumis followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro. Objectives: To determine whether dysregulated ECM production by the e...

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Bibliographic Details
Main Authors: Kicic, Anthony, Hallstrand, T.S., Sutanto, E.N., Stevens, P.T., Kobor, M.S., Taplin, C., Paré, P.D., Beyer, R.P., Stick, S.M., Knight, D.A.
Format: Journal Article
Language:English
Published: AMER THORACIC SOC 2010
Subjects:
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
fibronectin
asthma
epithelium
wound repair
inflammation
OBSTRUCTIVE PULMONARY-DISEASE
GROWTH-FACTOR RECEPTOR
GENE-EXPRESSION
AIRWAY EPITHELIUM
INHALED CORTICOSTEROIDS
BRONCHIAL EPITHELIUM
IN-VIVO
CELL-PROLIFERATION
ALLERGEN CHALLENGE
PEDIATRIC-AIRWAY
Online Access:http://hdl.handle.net/20.500.11937/76818

Internet

http://hdl.handle.net/20.500.11937/76818

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