Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

© ERS 2015. Neutrophil elastase is the most significant predictor of bronchiectasis in early-life cystic fibrosis; however, the causal link between neutrophil elastase and airway damage is not well understood. Matrix metalloproteinases (MMPs) play a crucial role in extracellular matrix modelling and...

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Bibliographic Details
Main Authors: Garratt, L.W., Sutanto, E.N., Ling, K.M., Looi, K., Iosifidis, T., Martinovich, K.M., Shaw, N.C., Kicic-Starcevich, E., Knight, D.A., Ranganathan, S., Stick, S.M., Kicic, Anthony
Format: Journal Article
Language:English
Published: EUROPEAN RESPIRATORY SOC JOURNALS LTD 2015
Subjects:
Science & Technology
Life Sciences & Biomedicine
Respiratory System
LOWER AIRWAY INFLAMMATION
LUNG-DISEASE
EPITHELIAL-CELLS
YOUNG-CHILDREN
CATHEPSIN-G
INHIBITORS
PSEUDOMONAS
EXPRESSION
INFANTS
SPUTUM
Online Access:http://hdl.handle.net/20.500.11937/76817

Internet

http://hdl.handle.net/20.500.11937/76817

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