Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair

Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair

© 2015 Elsevier Ltd. The epithelium of asthmatics is characterized by reduced expression of E-cadherin and increased expression of the basal cell markers ck-5 and p63 that is indicative of a relatively undifferentiated repairing epithelium. This phenotype correlates with increased proliferation, com...

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Bibliographic Details
Main Authors: Moheimani, F., Roth, H.M., Cross, J., Reid, A.T., Shaheen, F., Warner, S.M., Hirota, J.A., Kicic, Anthony, Hallstrand, T.S., Kahn, M., Stick, S.M., Hansbro, P.M., Hackett, T.L., Knight, D.A.
Format: Journal Article
Language:English
Published: PERGAMON-ELSEVIER SCIENCE LTD 2015
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Airway epithelium
beta-Catenin/CBP
ICG-001
Epithelial-mesenchymal transition
Wound repair
SUBMUCOSAL GLAND MORPHOGENESIS
ASTHMATIC EPITHELIUM
DYSREGULATED REPAIR
TUMOR-SUPPRESSOR
PROTEIN CBP
CELLS
EXPRESSION
FIBROSIS
PATHWAY
LUNG
Online Access:http://hdl.handle.net/20.500.11937/76815

Internet

http://hdl.handle.net/20.500.11937/76815

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