Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches
© 2017 Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
PERGAMON-ELSEVIER SCIENCE LTD
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/76808 |
| _version_ | 1848763765325037568 |
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| author | Reid, A.T. Veerati, P.C. Gosens, R. Bartlett, N.W. Wark, P.A. Grainge, C.L. Stick, S.M. Kicic, Anthony Moheimani, F. Hansbro, P.M. Knight, D.A. |
| author_facet | Reid, A.T. Veerati, P.C. Gosens, R. Bartlett, N.W. Wark, P.A. Grainge, C.L. Stick, S.M. Kicic, Anthony Moheimani, F. Hansbro, P.M. Knight, D.A. |
| author_sort | Reid, A.T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2017 Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology. |
| first_indexed | 2025-11-14T11:08:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-76808 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:08:40Z |
| publishDate | 2018 |
| publisher | PERGAMON-ELSEVIER SCIENCE LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-768082019-11-11T07:14:37Z Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches Reid, A.T. Veerati, P.C. Gosens, R. Bartlett, N.W. Wark, P.A. Grainge, C.L. Stick, S.M. Kicic, Anthony Moheimani, F. Hansbro, P.M. Knight, D.A. Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy Goblet cell Asthma COPD Cystic fibrosis Mucus Epithelium Signaling pathways Therapeutic micro-RNA Mechanical stress Monoclonal antibody therapy GROWTH-FACTOR RECEPTOR BRONCHIAL EPITHELIAL-CELLS RECOMBINANT HUMAN INTERLEUKIN-5 OBSTRUCTIVE PULMONARY-DISEASE RESPIRATORY SYNCYTIAL VIRUS COLONY-STIMULATING FACTOR CYSTIC-FIBROSIS MUCUS OVERPRODUCTION NEBULIZED AMILORIDE MUCIN PRODUCTION © 2017 Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology. 2018 Journal Article http://hdl.handle.net/20.500.11937/76808 10.1016/j.pharmthera.2017.12.009 English PERGAMON-ELSEVIER SCIENCE LTD restricted |
| spellingShingle | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy Goblet cell Asthma COPD Cystic fibrosis Mucus Epithelium Signaling pathways Therapeutic micro-RNA Mechanical stress Monoclonal antibody therapy GROWTH-FACTOR RECEPTOR BRONCHIAL EPITHELIAL-CELLS RECOMBINANT HUMAN INTERLEUKIN-5 OBSTRUCTIVE PULMONARY-DISEASE RESPIRATORY SYNCYTIAL VIRUS COLONY-STIMULATING FACTOR CYSTIC-FIBROSIS MUCUS OVERPRODUCTION NEBULIZED AMILORIDE MUCIN PRODUCTION Reid, A.T. Veerati, P.C. Gosens, R. Bartlett, N.W. Wark, P.A. Grainge, C.L. Stick, S.M. Kicic, Anthony Moheimani, F. Hansbro, P.M. Knight, D.A. Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title | Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title_full | Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title_fullStr | Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title_full_unstemmed | Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title_short | Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches |
| title_sort | persistent induction of goblet cell differentiation in the airways: therapeutic approaches |
| topic | Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy Goblet cell Asthma COPD Cystic fibrosis Mucus Epithelium Signaling pathways Therapeutic micro-RNA Mechanical stress Monoclonal antibody therapy GROWTH-FACTOR RECEPTOR BRONCHIAL EPITHELIAL-CELLS RECOMBINANT HUMAN INTERLEUKIN-5 OBSTRUCTIVE PULMONARY-DISEASE RESPIRATORY SYNCYTIAL VIRUS COLONY-STIMULATING FACTOR CYSTIC-FIBROSIS MUCUS OVERPRODUCTION NEBULIZED AMILORIDE MUCIN PRODUCTION |
| url | http://hdl.handle.net/20.500.11937/76808 |