Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

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Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

Copyright © 2019 by the American Thoracic Society. Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlate...

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Bibliographic Details
Main Authors:	Margaroli, C., Garratt, L.W., Horati, H., Dittrich, A.S., Rosenow, T., Montgomery, S.T., Frey, D.L., Brown, M.R., Schultz, C., Guglani, L., Kicic, Anthony, Peng, L., Scholte, B.J., Mall, M.A., Janssens, H.M., Stick, S.M., Tirouvanziam, R.
Format:	Journal Article
Language:	English
Published:	AMER THORACIC SOC 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Critical Care Medicine Respiratory System General & Internal Medicine air trapping degranulation mucus plugging proteolysis scavenging YOUNG-CHILDREN INFLAMMATORY RESPONSES INNATE IMMUNITY DISEASE INFANTS PROGRESSION DIAGNOSIS BRONCHIECTASIS MACROPHAGES PSEUDOMONAS
Online Access:	http://hdl.handle.net/20.500.11937/76779

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