Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis

Copyright © 2019 by the American Thoracic Society. Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlate...

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Bibliographic Details
Main Authors: Margaroli, C., Garratt, L.W., Horati, H., Dittrich, A.S., Rosenow, T., Montgomery, S.T., Frey, D.L., Brown, M.R., Schultz, C., Guglani, L., Kicic, Anthony, Peng, L., Scholte, B.J., Mall, M.A., Janssens, H.M., Stick, S.M., Tirouvanziam, R.
Format: Journal Article
Language:English
Published: AMER THORACIC SOC 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
air trapping
degranulation
mucus plugging
proteolysis
scavenging
YOUNG-CHILDREN
INFLAMMATORY RESPONSES
INNATE IMMUNITY
DISEASE
INFANTS
PROGRESSION
DIAGNOSIS
BRONCHIECTASIS
MACROPHAGES
PSEUDOMONAS
Online Access:http://hdl.handle.net/20.500.11937/76779

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http://hdl.handle.net/20.500.11937/76779

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