Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine

Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine

Cystic fibrosis (CF) is an inherited disorder where individual disease etiology and response to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations and other genetic modifiers. CFTR regulates multiple mechanisms in a diverse range of epithelial tissues. In this Review...

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Bibliographic Details
Main Authors: Awatade, N., Wong, S., Hewson, C., Fawcett, L., Kicic, Anthony, Jaffe, A., Waters, S.
Format: Journal Article
Language:English
Published: FRONTIERS MEDIA SA 2018
Subjects:
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
cystic fibrosis
organoid
personalized medicine
CFTR
drug development
sweat chloride
CFTR modulator
INTESTINAL CURRENT MEASUREMENT
IN-VITRO
CFTR POTENTIATOR
TEZACAFTOR-IVACAFTOR
ION-TRANSPORT
REGENERATION
LUMACAFTOR
ABSORPTION
CORRECTORS
SPHEROIDS
Online Access:http://hdl.handle.net/20.500.11937/76772

Internet

http://hdl.handle.net/20.500.11937/76772

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