Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

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Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain. We also designe...

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Bibliographic Details
Main Authors:	Teyra, J., Singer, A., Schmitges, F., Jaynes, P., Kit Leng Lui, S., Polyak, M., Fodil, N., Krieger, J., Tong, J., Schwerdtfeger, C., Brasher, B., Ceccarelli, DFJ, Moffat, J., Sicheri, F., Moran, M., Gros, P., Eichhorn, Pieter, Lenter, M., Boehmelt, G., Sidhu, S.
Format:	Journal Article
Language:	English
Published:	CELL PRESS 2019
Subjects:	Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Biophysics Cell Biology CELL-CYCLE DEUBIQUITYLATING ENZYMES DEUBIQUITINATING ENZYMES E3 LIGASES PHOSPHORYLATION SPECIFICITY RECOGNITION CENTROSOME MODULATION DISCOVERY
Online Access:	http://hdl.handle.net/20.500.11937/75729

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