Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain. We also designe...

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Bibliographic Details
Main Authors: Teyra, J., Singer, A., Schmitges, F., Jaynes, P., Kit Leng Lui, S., Polyak, M., Fodil, N., Krieger, J., Tong, J., Schwerdtfeger, C., Brasher, B., Ceccarelli, DFJ, Moffat, J., Sicheri, F., Moran, M., Gros, P., Eichhorn, Pieter, Lenter, M., Boehmelt, G., Sidhu, S.
Format: Journal Article
Language:English
Published: CELL PRESS 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biophysics
Cell Biology
CELL-CYCLE
DEUBIQUITYLATING ENZYMES
DEUBIQUITINATING ENZYMES
E3 LIGASES
PHOSPHORYLATION
SPECIFICITY
RECOGNITION
CENTROSOME
MODULATION
DISCOVERY
Online Access:http://hdl.handle.net/20.500.11937/75729

Internet

http://hdl.handle.net/20.500.11937/75729

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