A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

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A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

Studies of Alzheimer's disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-speci...

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Bibliographic Details
Main Authors:	Porter, T., Burnham, S., Savage, G., Lim, Y., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, David, Verdile, Giuseppe, Villemagne, V., Laws, Simon
Format:	Journal Article
Language:	English
Published:	FRONTIERS MEDIA SA 2018
Subjects:	Science & Technology Life Sciences & Biomedicine Geriatrics & Gerontology Neurosciences Neurosciences & Neurology polygenic risk score Alzheimer's disease A beta-amyloid cognitive decline episodic memory TRANSCRIPTION FACTOR IMPAIRMENT BETA INDIVIDUALS PREDICTION BIOMARKERS PROTEIN MEF2C
Online Access:	http://hdl.handle.net/20.500.11937/75016

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