A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's Disease

Studies of Alzheimer's disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-speci...

Full description

Bibliographic Details
Main Authors: Porter, T., Burnham, S., Savage, G., Lim, Y., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, David, Verdile, Giuseppe, Villemagne, V., Laws, Simon
Format: Journal Article
Language:English
Published: FRONTIERS MEDIA SA 2018
Subjects:
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
Neurosciences
Neurosciences & Neurology
polygenic risk score
Alzheimer's disease
A beta-amyloid
cognitive decline
episodic memory
TRANSCRIPTION FACTOR
IMPAIRMENT
BETA
INDIVIDUALS
PREDICTION
BIOMARKERS
PROTEIN
MEF2C
Online Access:http://hdl.handle.net/20.500.11937/75016

Internet

http://hdl.handle.net/20.500.11937/75016

Similar Items