Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7hi versus IRF7lo molecular phenotypes, the former exhibiti...

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Bibliographic Details
Main Authors: Khoo, S., Read, J., Franks, K., Zhang, Guicheng, Bizzintino, J., Coleman, L., McCrae, C., Öberg, L., Troy, N., Prastanti, F., Everard, J., Oo, S., Borland, M., Maciewicz, R., Le Souëf, P., Laing, I., Bosco, A.
Format: Journal Article
Published: 2019
Online Access:http://hdl.handle.net/20.500.11937/74236

Internet

http://hdl.handle.net/20.500.11937/74236

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