Epigenetic demthylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells.

QR Code

Epigenetic demthylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells.

The expression and levels of secreted frizzled-related proteins (sFRPs), important Wnt signalling antagonists, have been reported to be reduced in various cancers, and are associated with disease progression and poor prognosis. During tumour development, all sFRP (1, 2, 3, 4, and 5) genes are hyperm...

Full description

Bibliographic Details
Main Authors:	Deshmukh, A., Arfuso, F., Newsholme, P., Dharmarajan, Arunasalam
Format:	Journal Article
Published:	Pergamon 2019
Online Access:	http://hdl.handle.net/20.500.11937/74047

Similar Items

Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines
by: Deshmukh, A., et al.
Published: (2017)

Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma
by: Bhuvanalakshmi, G., et al.
Published: (2019)

The Role of Secreted Frizzled-related Protein-4 (sFRP4) in the Epigenetics, Metabolism and Chemo-sensitisation of Cancer Stem Cells
by: Deshmukh, Abhijeet Popatrao
Published: (2017)

Regulation of cancer stem cell metabolism by secreted frizzled-related protein 4 (SFRP4)
by: Deshmukh, Abhijeet, et al.
Published: (2018)

Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), increases chemotherapeutic response of glioma stem-like cells
by: Warrier, S., et al.
Published: (2014)

SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease
by: Warrier, Sudha, et al.
Published: (2016)

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition
by: Warrier, Sudha, et al.
Published: (2014)

The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain
by: Perumal, Vanathi, et al.
Published: (2017)

Role of epigenetic modulation in cancer stem cell fate
by: Deshmukh, A., et al.
Published: (2017)

Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a
by: Perumal, V., et al.
Published: (2015)

The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line
by: McLaren, S., et al.
Published: (2014)

Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt
by: Visweswaran, Malini, et al.
Published: (2015)

Wnt antagonist, secreted frizzled-related protein 4 (SFRP4) and peptides from its associated domains, increases chemotherapeutic response of cancer stem cells of malignant mesothelioma cell lines
by: Perumal, V., et al.
Published: (2017)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators
by: Bhuvanalakshmi, G., et al.
Published: (2017)

SFRP-4 abrogates Wnt-3a-induced ß-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation
by: Constantinou, T., et al.
Published: (2008)

Secreted Frizzled related protein-4 (sFRP4) promotes epidermal differentiation and apoptosis
by: Maganga, R., et al.
Published: (2008)

The role of Wnt signalling in angiogenesis
by: Olsen, J., et al.
Published: (2017)

Role of Wnt signalling in early pregnancy
by: Nayeem, S., et al.
Published: (2015)

The inhibitory influence of adipose tissue-derived mesenchymal stem cell environment and Wnt antagonism on breast tumour cell lines
by: Visweswaran, M., et al.
Published: (2017)

Wnt signaling in triple-negative breast cancer
by: Pohl, S., et al.
Published: (2017)

The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts
by: Visweswaran, M., et al.
Published: (2018)

The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity
by: Perumal, Vanathi
Published: (2014)

Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells
by: Visweswaran, Malini, et al.
Published: (2015)

Life cycle assessment of ramie fiber used for FRPs
by: Dong, Shaoce, et al.
Published: (2018)

Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme
by: Schiefer, L., et al.
Published: (2014)

Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays
by: Berry, A., et al.
Published: (2014)

Cancer stem cell metabolism: A potential target for cancer therapy
by: Deshmukh, A., et al.
Published: (2016)

SFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium
by: Saran, U., et al.
Published: (2017)

Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domain
by: Agostino, M., et al.
Published: (2017)

Paracrine communication modulates production of Wnt antagonists and COX1-mediated prostaglandins in a decidual-trophoblast co-culture model
by: Nayeem, S., et al.
Published: (2015)

Analysis of histone deacetylation as an epigenetic factor in somaclonal variation of Ananas comosus variety MD2 / Nur Asniyati Abdul Halim
by: Nur Asniyati , Abdul Halim
Published: (2018)

FRP sheets contribution in common repair techniques of concrete structures with emphasis on concrete columns
by: Panjehpour, Mohammad, et al.
Published: (2011)

Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells
by: Perumal, Vanathi, et al.
Published: (2015)

Role of novel histone modifications in cancer
by: Shanmugam, M., et al.
Published: (2018)

Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt ß-catenin signaling via the Wnt antagonist secreted frizzled related protein-4
by: Bhuvanalakshmi, G., et al.
Published: (2017)

Wnt/ß-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
by: Shirolkar, Gayatri, et al.
Published: (2018)

Treatment of colorectal cancer cells with nanocarrier encap-sulated camptothecin reveals histone modifier genes in the Wnt signaling pathway as important molecular cues for cancer targeting
by: Aisha Farhana, et al.
Published: (2021)

Epigenetic effects of metformin: From molecular mechanisms to clinical implications
by: Bridgeman, S., et al.
Published: (2018)

‘Lnc’-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling
by: Ong, M., et al.
Published: (2017)

Kanser ovari paling 'misteri'
by: Ariffin, Latifah
Published: (2022)