Epigenetic demthylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells.
The expression and levels of secreted frizzled-related proteins (sFRPs), important Wnt signalling antagonists, have been reported to be reduced in various cancers, and are associated with disease progression and poor prognosis. During tumour development, all sFRP (1, 2, 3, 4, and 5) genes are hyperm...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Pergamon
2019
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| Online Access: | http://hdl.handle.net/20.500.11937/74047 |