Reduced prothrombinase inhibition by tissue factor pathway inhibitor contributes to the factor V Leiden hypercoagulable state

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Reduced prothrombinase inhibition by tissue factor pathway inhibitor contributes to the factor V Leiden hypercoagulable state

Activated factor V (FVa) and factor X (FXa) form prothrombinase, which converts prothrombin to thrombin. The a isoform of tissue factor (TF) pathway inhibitor (TFPI) dampens early procoagulant events, partly by interacting with FV. FV Leiden (FVL) is the most common genetic thrombophilia in Caucasia...

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Bibliographic Details
Main Authors:	Wood, J., Kreuziger, L., Ellery, Paul, Maroney, S., Mast, A.
Format:	Journal Article
Published:	AMER SOC HEMATOLOGY 2017
Online Access:	http://hdl.handle.net/20.500.11937/73365

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