Reduced prothrombinase inhibition by tissue factor pathway inhibitor contributes to the factor V Leiden hypercoagulable state
Activated factor V (FVa) and factor X (FXa) form prothrombinase, which converts prothrombin to thrombin. The a isoform of tissue factor (TF) pathway inhibitor (TFPI) dampens early procoagulant events, partly by interacting with FV. FV Leiden (FVL) is the most common genetic thrombophilia in Caucasia...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
AMER SOC HEMATOLOGY
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/73365 |