Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease

Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease

The overwhelming majority of dominant mutations causing early onset familial Alzheimer's disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP. An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid ß (Aß). It is this key fact that unde...

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Bibliographic Details
Main Authors: Lumsden, A., Rogers, J., Majd, S., Newman, M., Sutherland, G., Verdile, Giuseppe, Lardelli, M.
Format: Journal Article
Published: Frontiers Research Foundation 2018
Online Access:http://hdl.handle.net/20.500.11937/72485

Internet

http://hdl.handle.net/20.500.11937/72485

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