Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility
Silybin (SLB), a kind of antihepatotoxic polyphenolic substance, is currently available for a variety of acute and chronic liver diseases. However, its poor solubility and low bioavailability have strongly limited its therapeutic applications. In this work, we demonstrate a simple solution to addres...
| Main Authors: | , , , , |
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| Format: | Journal Article |
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American Chemical Society
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/72404 |
| _version_ | 1848762741534228480 |
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| author | Teng, W. Wang, J. Foster, Neil Wen, N. Zhang, J. |
| author_facet | Teng, W. Wang, J. Foster, Neil Wen, N. Zhang, J. |
| author_sort | Teng, W. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Silybin (SLB), a kind of antihepatotoxic polyphenolic substance, is currently available for a variety of acute and chronic liver diseases. However, its poor solubility and low bioavailability have strongly limited its therapeutic applications. In this work, we demonstrate a simple solution to address these issues by designing SLB/poly(vinylpyrrolidone) (PVP) nanodrugs via the aerosol solvent extraction system (ASES). In the ASES process, SLB and PVP are prepared via coprecipitation by using the dimethylformamide/dense gas CO2solvent/antisolvent strategy. The size of the as-obtained SLB/PVP nanodrugs (denoted as NanoSLB) can be tuned from 100 to 300 nm. Compared with raw SLB, NanoSLB is of low crystallinity and hence shows drug solubility greatly enhanced by more than 8-fold. This work will broaden the applications of water-insoluble drugs in pharmaceutical treatments. © 2014 American Chemical Society. |
| first_indexed | 2025-11-14T10:52:23Z |
| format | Journal Article |
| id | curtin-20.500.11937-72404 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:52:23Z |
| publishDate | 2014 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-724042018-12-13T09:33:19Z Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility Teng, W. Wang, J. Foster, Neil Wen, N. Zhang, J. Silybin (SLB), a kind of antihepatotoxic polyphenolic substance, is currently available for a variety of acute and chronic liver diseases. However, its poor solubility and low bioavailability have strongly limited its therapeutic applications. In this work, we demonstrate a simple solution to address these issues by designing SLB/poly(vinylpyrrolidone) (PVP) nanodrugs via the aerosol solvent extraction system (ASES). In the ASES process, SLB and PVP are prepared via coprecipitation by using the dimethylformamide/dense gas CO2solvent/antisolvent strategy. The size of the as-obtained SLB/PVP nanodrugs (denoted as NanoSLB) can be tuned from 100 to 300 nm. Compared with raw SLB, NanoSLB is of low crystallinity and hence shows drug solubility greatly enhanced by more than 8-fold. This work will broaden the applications of water-insoluble drugs in pharmaceutical treatments. © 2014 American Chemical Society. 2014 Journal Article http://hdl.handle.net/20.500.11937/72404 10.1021/ie501147f American Chemical Society restricted |
| spellingShingle | Teng, W. Wang, J. Foster, Neil Wen, N. Zhang, J. Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title | Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title_full | Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title_fullStr | Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title_full_unstemmed | Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title_short | Preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| title_sort | preparation of silybin/poly(vinylpyrrolidone) nanodrugs by using the aerosol solvent extraction system for improving drug solubility |
| url | http://hdl.handle.net/20.500.11937/72404 |