Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes

QR Code

Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes

© 2018 The British Pharmacological Society Aims: Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NE...

Full description

Bibliographic Details
Main Authors:	Salman, S., Hibbert, J., Page-Sharp, Madhu, Manning, L., Simmer, K., Doherty, D., Patole, S., Batty, Kevin, Strunk, T.
Format:	Journal Article
Published:	Wiley-Blackwell Publishing Ltd. 2018
Online Access:	http://hdl.handle.net/20.500.11937/72063

Similar Items

Simultaneous determination of pentoxifylline, metabolites M1 (lisofylline), M4 and M5, and caffeine in plasma and dried blood spots for pharmacokinetic studies in preterm infants and neonates
by: Page-Sharp, Madhu, et al.
Published: (2017)

Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants
by: Strunk, T., et al.
Published: (2012)

Physical compatibility of pentoxifylline and intravenous medications.
by: Senarathna, S., et al.
Published: (2018)

Antimicrobial Protein and Peptide Concentrations and Activity in Human Breast Milk Consumed by Preterm Infants at Risk of Late-Onset Neonatal Sepsis
by: Trend, S., et al.
Published: (2015)

Compatibility of pentoxifylline and parenteral medications
by: Campbell, A.L., et al.
Published: (2020)

Stability of Pentoxifylline Injection: Application to Neonatal/Pediatric Care Setting
by: Senarathna, S.M.D.K.G., et al.
Published: (2021)

Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations
by: Chambers, J., et al.
Published: (2018)

Pharmacokinetics, Pharmacodynamics and Allometric Scaling of Chloroquine in a Murine Malaria Model
by: Moore, Brioni, et al.
Published: (2011)

Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk
by: Wan, E., et al.
Published: (2008)

Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: A randomized, crossover, population pharmacokinetic study in healthy adult volunteers
by: Kado, J.H., et al.
Published: (2020)

Does after-hours in-house senior physician cover improve standard of care and outcomes in high-risk preterm neonates? A retrospective cohort study
by: Resnick, S., et al.
Published: (2011)

Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers
by: Moore, B., et al.
Published: (2015)

Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
by: Salman, S., et al.
Published: (2011)

Population pharmacokinetic study of ceftriaxone in elderly patients, using cystatin C-based estimates of renal function to account for frailty
by: Tan, S.J., et al.
Published: (2020)

Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model
by: Moore, Brioni, et al.
Published: (2008)

Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria
by: Salman, S., et al.
Published: (2012)

The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children
by: Sugiarto, S.R., et al.
Published: (2022)

Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy
by: Karunajeewa, H., et al.
Published: (2010)

Toxicology and pharmacokinetics of piperaquine in mice
by: Batty, Kevin, et al.
Published: (2008)

Necrotic ulcers in an immunocompromised patient
by: Wan Ahmad Kammal, Wan Syazween Lyana, et al.
Published: (2022)

Evaluation of the current practices and effectiveness of empiric antibiotic therapy in neonates suspected of early onset sepsis in three tertiary hospitals / Nazedah Ain @ Ibrahim
by: Ain @ Ibrahim, Nazedah
Published: (2015)

Pharmacokinetics of transfer of azithromycin into the breast milk of African mothers
by: Salman, S., et al.
Published: (2016)

Post-discharge nutrition for high-risk preterm neonates
by: McLeod, G., et al.
Published: (2013)

Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women
by: Karunajeewa, H., et al.
Published: (2009)

Stability of benzylpenicillin for continuous intravenous infusions: An isotonic formulation for therapeutic use and a low-dose formulation for clinical trial
by: Batty, Kevin, et al.
Published: (2022)

Use of quantitative pharmacology tools to improve malaria treatments
by: Davis, T., et al.
Published: (2015)

Population pharmacokinetics of doripenem in critically ill patients with sepsis in a Malaysian intensive care unit
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2016)

Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
by: Abdul Aziz, Mohd. Hafiz, et al.
Published: (2014)

Effect of coadministered fat on the tolerability, safety and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria
by: Moore, Brioni, et al.
Published: (2014)

Population Pharmacokinetics of Artemether, Lumefantrine, and Their Respective Metabolites in Papua New Guinean Children with Uncomplicated Malaria
by: Salman, S., et al.
Published: (2011)

Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease
by: Ferrari, P., et al.
Published: (2010)

Artemisinin-Naphthoquine Combination Therapy for Uncomplicated Pediatric Malaria: a Pharmacokinetic Study
by: Batty, Kevin, et al.
Published: (2012)

PHARMACOKINETICS OF TRANSFER OF PIPERAQUINE INTO THE BREAST MILK OF PAPUA NEW GUINEAN MOTHERS
by: Moore, B., et al.
Published: (2015)

Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women
by: Benjamin, J., et al.
Published: (2015)

Necrotizing autoimmune myopathy: a case series
by: Sulaiman Sahari, Narisa, et al.
Published: (2020)

Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling
by: Salman, S., et al.
Published: (2017)

Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria
by: Karunajeewa, H., et al.
Published: (2008)

Pharmacokinetic properties of single-dose primaquine in Papua New Guinean children: Feasibility of abbreviated high-dose regimens for radical cure of vivax malaria
by: Moore, Brioni, et al.
Published: (2014)

Optimal antimalarial dose regimens for sulfadoxine-pyrimethamine with or without azithromycin in pregnancy based on population pharmacokinetic modeling
by: Salman, S., et al.
Published: (2017)

Dysphonia in very preterm children: a review of the evidence
by: Reynolds, Mary, et al.
Published: (2014)