Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

© 2017 The Author(s) Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indicating improved proinsulin con...

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Bibliographic Details
Main Authors: Carrat, G., Hu, M., Nguyen-Tu, M., Chabosseau, P., Gaulton, K., van de Bunt, M., Siddiq, A., Falchi, M., Thurner, M., Canouil, M., Pattou, F., Leclerc, I., Pullen, T., Cane, M., Prabhala, P., Greenwald, W., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P., Manning Fox, J., Gloyn, A., Froguel, P., Solimena, Michele, McCarthy, M., Rutter, G.
Format: Journal Article
Published: Cell Press 2017
Online Access:http://hdl.handle.net/20.500.11937/71395

Internet

http://hdl.handle.net/20.500.11937/71395

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