Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

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Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects

Antitumor efficacy of ursolic acid (UA) is seriously limited due to its low hydrophilicity and needy bioavailability. To overcome these obstacles, chemosensitive polyspermine (CPSP) conjugated with UA and folic acid (FA) as a novel targeted prodrug was designed and successfully synthesized in this i...

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Bibliographic Details
Main Authors:	Ji, X., Tang, Q., Pang, P., Wu, Jian-Ping, Kirk, Brett, Xu, J., Ma, D., Xue, W.
Format:	Journal Article
Published:	Elsevier BV 2018
Online Access:	http://hdl.handle.net/20.500.11937/69990

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