Redox-responsive chemosensitive polyspermine delivers ursolic acid targeting to human breast tumor cells: The depletion of intracellular GSH contents arouses chemosensitizing effects
Antitumor efficacy of ursolic acid (UA) is seriously limited due to its low hydrophilicity and needy bioavailability. To overcome these obstacles, chemosensitive polyspermine (CPSP) conjugated with UA and folic acid (FA) as a novel targeted prodrug was designed and successfully synthesized in this i...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/69990 |