A model-based control scheme for depth of hypnosis in anesthesia
© 2018 Elsevier Ltd. In this paper we propose a model-based scheme to control the depth of hypnosis in anesthesia that uses the BIS signal as controlled variable. In particular, the control scheme exploits the propofol pharmacokinetics/pharmacodynamics model of the patient so that the estimated effe...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/66178 |
| _version_ | 1848761257183674368 |
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| author | Merigo, L. Padula, Fabrizio Pawlowski, A. Dormido, S. Guzmán Sánchez, J. Latronico, N. Paltenghi, M. Visioli, A. |
| author_facet | Merigo, L. Padula, Fabrizio Pawlowski, A. Dormido, S. Guzmán Sánchez, J. Latronico, N. Paltenghi, M. Visioli, A. |
| author_sort | Merigo, L. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2018 Elsevier Ltd. In this paper we propose a model-based scheme to control the depth of hypnosis in anesthesia that uses the BIS signal as controlled variable. In particular, the control scheme exploits the propofol pharmacokinetics/pharmacodynamics model of the patient so that the estimated effect-site concentration is used as a feedback signal for a standard PID controller, which compensates for the model uncertainties. The tuning of the parameters is performed off-line using genetic algorithms to minimize a performance index over a given data set of patients. The effectiveness of the proposed method is verified by means of a Monte Carlo method that takes into account both the intra-patient and inter-patient variability. In general, we obtain a fast induction phase with limited overshoot and a good disturbance rejection during maintenance of anesthesia. |
| first_indexed | 2025-11-14T10:28:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-66178 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:28:48Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-661782018-06-12T06:47:56Z A model-based control scheme for depth of hypnosis in anesthesia Merigo, L. Padula, Fabrizio Pawlowski, A. Dormido, S. Guzmán Sánchez, J. Latronico, N. Paltenghi, M. Visioli, A. © 2018 Elsevier Ltd. In this paper we propose a model-based scheme to control the depth of hypnosis in anesthesia that uses the BIS signal as controlled variable. In particular, the control scheme exploits the propofol pharmacokinetics/pharmacodynamics model of the patient so that the estimated effect-site concentration is used as a feedback signal for a standard PID controller, which compensates for the model uncertainties. The tuning of the parameters is performed off-line using genetic algorithms to minimize a performance index over a given data set of patients. The effectiveness of the proposed method is verified by means of a Monte Carlo method that takes into account both the intra-patient and inter-patient variability. In general, we obtain a fast induction phase with limited overshoot and a good disturbance rejection during maintenance of anesthesia. 2018 Journal Article http://hdl.handle.net/20.500.11937/66178 10.1016/j.bspc.2018.01.023 restricted |
| spellingShingle | Merigo, L. Padula, Fabrizio Pawlowski, A. Dormido, S. Guzmán Sánchez, J. Latronico, N. Paltenghi, M. Visioli, A. A model-based control scheme for depth of hypnosis in anesthesia |
| title | A model-based control scheme for depth of hypnosis in anesthesia |
| title_full | A model-based control scheme for depth of hypnosis in anesthesia |
| title_fullStr | A model-based control scheme for depth of hypnosis in anesthesia |
| title_full_unstemmed | A model-based control scheme for depth of hypnosis in anesthesia |
| title_short | A model-based control scheme for depth of hypnosis in anesthesia |
| title_sort | model-based control scheme for depth of hypnosis in anesthesia |
| url | http://hdl.handle.net/20.500.11937/66178 |