Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors

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Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors

© The Royal Society of Chemistry 2018. Herein we describe the design, synthesis, and biological evaluation of a novel series of tranylcypromine-based LSD1 inhibitors via conformational restriction using spiro ring systems. A simple, direct spirocyclic analog of tranylcypromine (compounds 8a and 8b)...

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Bibliographic Details
Main Authors:	Shi, Y., Wu, Y., Su, M., Shen, D., Gunosewoyo, Hendra, Yang, F., Li, J., Tang, J., Zhou, Y., Yu, L.
Format:	Journal Article
Published:	Royal Society of Chemistry 2018
Online Access:	http://hdl.handle.net/20.500.11937/65805

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