Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
© The Royal Society of Chemistry 2018. Herein we describe the design, synthesis, and biological evaluation of a novel series of tranylcypromine-based LSD1 inhibitors via conformational restriction using spiro ring systems. A simple, direct spirocyclic analog of tranylcypromine (compounds 8a and 8b)...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Royal Society of Chemistry
2018
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| Online Access: | http://hdl.handle.net/20.500.11937/65805 |