Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic ß-cell bioenergetic parameters and metabolism in BRIN-BD11 cells

QR Code

Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic ß-cell bioenergetic parameters and metabolism in BRIN-BD11 cells

Pharmacological long lasting Glucagon-like peptide-1 (GLP-1) analogues, such as Exendin-4, have become widely used diabetes therapies. Chronic GLP-1R stimulation has been linked to ß-cell protection and these pro-survival actions of GLP-1 are dependent on the activation of the mammalian target of ra...

Full description

Bibliographic Details
Main Authors:	Rowlands, Jordan, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip
Format:	Journal Article
Published:	Elsevier 2018
Online Access:	http://hdl.handle.net/20.500.11937/65488

Similar Items

Method Protocols for Metabolic and Functional Analysis of the BRIN-BD11 ß-Cell Line: A Preclinical Model for Type 2 Diabetes
by: Rowlands, J., et al.
Published: (2019)

Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)

Lupin seed hydrolysate promotes G-protein-coupled receptor, intracellular Ca2+ and enhanced glycolytic metabolism-mediated insulin secretion from BRIN-BD11 pancreatic beta cells
by: Tapadia, M., et al.
Published: (2018)

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 ß-cell insulin secretion and signal transduction
by: Kiely, A., et al.
Published: (2009)

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism
by: Bender, K., et al.
Published: (2009)

Cytotoxicity and cytoprotective effects of citrus flavonoids on insulin-secreting cells BRIN-BD11: beneficial synergic effects.
by: Felipe, E., et al.
Published: (2013)

Alanyl-glutamine improves pancreatic ß-cell function following ex vivo inflammatory challenge
by: Cruzat, Vinicius, et al.
Published: (2015)

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and ß-Cell Dysfunction
by: Keane, Kevin, et al.
Published: (2015)

Effects of oil palm (Elaeis guineensis) fruit extracts on insulin secretion from BRIN BD11 cells
by: Sharif, Faez, et al.
Published: (2015)

The bioenergetics of inflammation: insights into obesity and type 2 diabetes
by: Keane, Kevin, et al.
Published: (2017)

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics
by: Keane, Kevin, et al.
Published: (2015)

The growth culture of BRIN-BD11 producing insulin in different type of microcarriers
by: Mel, Maizirwan, et al.
Published: (2011)

Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adults
by: Calton, Emily, et al.
Published: (2016)

Nutrient regulation of ß-cell function: what do islet cell/animal studies tell us?
by: Carlessi, Rodrigo, et al.
Published: (2017)

Comparing BRIN-BD11 culture producing insulin using different type of microcarriers
by: Mel, Maizirwan, et al.
Published: (2010)

Peroxiredoxin III protects pancreatic ß cells from apoptosis
by: Wolf, G., et al.
Published: (2010)

Exendin-4 attenuates brain death-induced liver damage in the rat
by: Carlessi, Rodrigo, et al.
Published: (2015)

Optimization of modified-media containing serum for better rin-5f and brin-bd11 cells monolayer attachment, growth and insulin secretion
by: Abdul Karim, Mohamed Ismail
Published: (2009)

Winter to summer change in vitamin D status reduces systemic inflammation and bioenergetic activity of human peripheral blood mononuclear cells
by: Calton, E., et al.
Published: (2017)

Exendin-4 protects rat islets against loss of viability and function induced by brain death
by: Carlessi, Rodrigo, et al.
Published: (2014)

Biological Assessments of Encapsulated Pancreatic ß-Cells: Their Potential Transplantation in Diabetes
by: Mooranian, Armin, et al.
Published: (2016)

Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells
by: Keane, D., et al.
Published: (2008)

The Impact of Inflammation on Pancreatic ß-Cell Metabolism, Function and Failure in T1DM and T2DM: Commonalities and Differences
by: Newsholme, Philip, et al.
Published: (2013)

Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics
by: Elmorsy, Ekramy, et al.
Published: (2015)

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells
by: Elmorsy, Ekramy, et al.
Published: (2017)

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
by: Pieiro, R., et al.
Published: (2011)

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic ß-cell line
by: Keane, D., et al.
Published: (2011)

Designing anti-diabetic ß-cells microcapsules using polystyrenic sulfonate, polyallylamine and a tertiary bile acid: Morphology, bioenergetics and cytokine analysis.
by: Mooranian, A., et al.
Published: (2016)

Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics
by: Elsheikha, Hany M., et al.
Published: (2013)

Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity
by: Carlessi, Rodrigo, et al.
Published: (2018)

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
by: Carlessi, Rodrigo, et al.
Published: (2017)

β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes
by: Chen, Y., et al.
Published: (2016)

IGF-1 protein expression in cultured CHO cells
by: Packeer Mohammed, Vasila, et al.
Published: (2010)

Characterization of a novel bile acid-based delivery platform for microencapsulated pancreatic ß-cells.
by: Mooranian, Armin, et al.
Published: (2014)

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic ß cells
by: Dominguez, V., et al.
Published: (2011)

Prolonged L-alanine exposure induces changes in metabolism, Ca2+ handling and desensitization of insulin secretion in clonal pancreatic ß-cells
by: McClenaghan, N., et al.
Published: (2009)

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics
by: Elmorsy, E., et al.
Published: (2016)

Molecular mechanisms of ROS production and oxidative stress in diabetes
by: Newsholme, Philip, et al.
Published: (2016)

Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic ß cells
by: Mooranian, A., et al.
Published: (2017)

Nutrient regulation of insulin secretion and ß-cell functional integrity
by: Newsholme, Philip, et al.
Published: (2010)