Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist
The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ), a...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Elsevier Masson
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/63365 |
| _version_ | 1848761069113180160 |
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| author | Bajare, S. Anthony, J. Nair, A. Marita, R. Damre, A. Patel, Dharmeshkumar Rao, C. Sivaramakrishnan, H. Deka, N. |
| author_facet | Bajare, S. Anthony, J. Nair, A. Marita, R. Damre, A. Patel, Dharmeshkumar Rao, C. Sivaramakrishnan, H. Deka, N. |
| author_sort | Bajare, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor. Ligands for PPARγ regulate adipocyte production and secretion of fatty acids as well as glucose metabolism, resulting in increased insulin sensitivity in adipose tissue, liver, and skeletal muscle. However, TZDs have several adverse effects, including weight gain and liver toxicity. Herein we report identification of non-TZD PPARγ agonists which exhibit beneficial effects similar to that of TZDs in animal models, but without the associated adverse effects. © 2012 Elsevier Masson SAS. All rights reserved. |
| first_indexed | 2025-11-14T10:25:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-63365 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:25:48Z |
| publishDate | 2012 |
| publisher | Elsevier Masson |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-633652018-02-06T07:41:46Z Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist Bajare, S. Anthony, J. Nair, A. Marita, R. Damre, A. Patel, Dharmeshkumar Rao, C. Sivaramakrishnan, H. Deka, N. The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor. Ligands for PPARγ regulate adipocyte production and secretion of fatty acids as well as glucose metabolism, resulting in increased insulin sensitivity in adipose tissue, liver, and skeletal muscle. However, TZDs have several adverse effects, including weight gain and liver toxicity. Herein we report identification of non-TZD PPARγ agonists which exhibit beneficial effects similar to that of TZDs in animal models, but without the associated adverse effects. © 2012 Elsevier Masson SAS. All rights reserved. 2012 Journal Article http://hdl.handle.net/20.500.11937/63365 10.1016/j.ejmech.2012.10.027 Elsevier Masson restricted |
| spellingShingle | Bajare, S. Anthony, J. Nair, A. Marita, R. Damre, A. Patel, Dharmeshkumar Rao, C. Sivaramakrishnan, H. Deka, N. Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title | Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title_full | Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title_fullStr | Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title_full_unstemmed | Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title_short | Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist |
| title_sort | synthesis of n-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl) benzenesulfonamide derivatives as non-tzd peroxisome proliferator-activated receptor î³ (pparî³) agonist |
| url | http://hdl.handle.net/20.500.11937/63365 |