Computational site-directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase

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Computational site-directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase

Â© 2017 Wiley Periodicals, Inc. Cholesterol oxidase (ChOx) is a flavoenzyme that oxidizes and isomerizes cholesterol (CHL) to form cholest-4-en-3-one. Molecular docking and molecular dynamics simulations were conducted to predict the binding interactions of CHL in the active site. Several key intera...

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Bibliographic Details
Main Authors:	Harb, L., Arooj, Mahreen, Vrielink, A., Mancera, Ricardo
Format:	Journal Article
Published:	John Wiley & Sons, Inc. 2017
Online Access:	http://hdl.handle.net/20.500.11937/63291

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