Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator
Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns associated with TZDs. It was unclear whether the sid...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Birkhaeuser Science
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/63091 |
| _version_ | 1848760992004046848 |
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| author | Deka, N. Uravane, M. Anthony, J. Bhumra, S. Nair, A. B-Rao, C. Patel, Dharmeshkumar Sivaramakrishnan, H. |
| author_facet | Deka, N. Uravane, M. Anthony, J. Bhumra, S. Nair, A. B-Rao, C. Patel, Dharmeshkumar Sivaramakrishnan, H. |
| author_sort | Deka, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns associated with TZDs. It was unclear whether the side effects observed are target mediated or compound mediated, but most of the TZDs activate PPARγ. This obliged developing of a new diverse class of ligands as antihyperglycemic agents including non-TZD PPAR ligands that could be highly effective, safe, and devoid of side effects. Here, we report the design and synthesis of N-(5-chloro-6-((1-phenylpiperidin-4-yl)oxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD PPARγ modulators. © Springer Science+Business Media 2013. |
| first_indexed | 2025-11-14T10:24:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-63091 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T10:24:35Z |
| publishDate | 2014 |
| publisher | Birkhaeuser Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-630912018-02-06T06:24:16Z Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator Deka, N. Uravane, M. Anthony, J. Bhumra, S. Nair, A. B-Rao, C. Patel, Dharmeshkumar Sivaramakrishnan, H. Thiazolidinediones (TZDs) are an important class of compound used for the treatment of type 2 diabetes, targeting the peroxisome proliferator-activated receptor γ (PPARγ). Drug-induced hepatotoxicity, edema, and weight gain are the main concerns associated with TZDs. It was unclear whether the side effects observed are target mediated or compound mediated, but most of the TZDs activate PPARγ. This obliged developing of a new diverse class of ligands as antihyperglycemic agents including non-TZD PPAR ligands that could be highly effective, safe, and devoid of side effects. Here, we report the design and synthesis of N-(5-chloro-6-((1-phenylpiperidin-4-yl)oxy)pyridin-3-yl) benzenesulfonamide derivatives as non-TZD PPARγ modulators. © Springer Science+Business Media 2013. 2014 Journal Article http://hdl.handle.net/20.500.11937/63091 10.1007/s00044-013-0814-y Birkhaeuser Science restricted |
| spellingShingle | Deka, N. Uravane, M. Anthony, J. Bhumra, S. Nair, A. B-Rao, C. Patel, Dharmeshkumar Sivaramakrishnan, H. Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title | Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title_full | Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title_fullStr | Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title_full_unstemmed | Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title_short | Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator |
| title_sort | design and synthesis of non-tzd peroxisome proliferator-activated receptor î³ (pparî³) modulator |
| url | http://hdl.handle.net/20.500.11937/63091 |