CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

CD4-binding site (CD4bs) alterations in gp120 contribute to different pathophysiological phenotypes of CCR5-using (R5) HIV-1 strains, but the potential structural basis is unknown. Here, we characterized functionally diverse R5 envelope (Env) clones (n = 16) to elucidate potential structural alterat...

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Bibliographic Details
Main Authors: Sterjovski, J., Churchill, M., Roche, M., Ellett, A., Farrugia, W., Wesselingh, S., Cunningham, A., Ramsland, Paul, Gorry, P.
Format: Journal Article
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/6288

Internet

http://hdl.handle.net/20.500.11937/6288

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