Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease

QR Code

Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease

Cystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary cirrhosis; however, its cause(s) and early pathogenesis are unclear. We hypothesized that a bile acid–induced ductular reaction (DR) drives fibrogenesis. The DR was evaluated by cytokeratin-7 immunohistoc...

Full description

Bibliographic Details
Main Authors:	Pozniak, K., Pearen, M., Pereira, T., Kramer, C., Kalita-De Croft, P., Nawaratna, S., Fernandez-Rojo, M., Gobert, G., Tirnitz-Parker, Nina, Olynyk, John, Shepherd, R., Lewindon, P., Ramm, G.
Format:	Journal Article
Published:	Elsevier Inc. 2017
Online Access:	http://hdl.handle.net/20.500.11937/59233

Similar Items

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation
by: Prakoso, E., et al.
Published: (2014)

The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis.
by: Köhn-Gaone, J., et al.
Published: (2016)

Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses
by: Tirnitz-Parker, Nina, et al.
Published: (2014)

Pioglitazone is anti-inflammatory in human liver and reduces stellate cell activation and proliferation
by: Abdul Rahim, Roslina, et al.
Published: (2011)

Lymphotoxin-beta Receptor Signaling Regulates Hepatic Stellate Cell Function and Wound Healing in a Murine Model of Chronic Liver Injury
by: Ruddell, R., et al.
Published: (2009)

Liver progenitor cells, cancer stem cells and hepatocellular carcinoma
by: Tirnitz-Parker, Nina, et al.
Published: (2012)

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury
by: Köhn-Gaone, J., et al.
Published: (2016)

Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells
by: Viebahn, C., et al.
Published: (2006)

A Transcriptomic Signature of Mouse Liver Progenitor Cells
by: Passman, A., et al.
Published: (2016)

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
by: Grzelak, C., et al.
Published: (2017)

Liver progenitor cell interactions with the extracellular matrix
by: Zhu, C., et al.
Published: (2012)

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration
by: Elsegood, Caryn, et al.
Published: (2015)

Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis
by: Köhn, Julia
Published: (2016)

TWEAK and LTß Signaling during Chronic Liver Disease
by: Dwyer, Benjamin, et al.
Published: (2014)

Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury
by: Viebahn, C., et al.
Published: (2010)

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis Is a Mitogen for Liver Progenitor Cells
by: Tirnitz-Parker, Nina, et al.
Published: (2010)

let-7g-5p suppresses the proliferation and expansion of hepatic stellate cells in liver fibrosis via targeting FGF5
by: Zhou, Jiaming, et al.
Published: (2025)

Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury
by: Knight, B., et al.
Published: (2005)

Expansion and Hepatocytic Differentiation of Liver Progenitor Cells In Vivo Using a Vascularized Tissue Engineering Chamber in Mice
by: Forster, N., et al.
Published: (2011)

Interferon-[gamma] exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury
by: Knight, B., et al.
Published: (2007)

C-kit Inhibition by Imatinib Mesylate Attenuates Progenitor Cell Expansion and Inhibits Liver Tumor Formation in Mice
by: Knight, B., et al.
Published: (2008)

Liver carcinogenesis
by: Tirnitz-Parker, Janina, et al.
Published: (2009)

CX3CR1 reduces choline-deficient, ethionine-supplemented diet-induced liver injury and liver progenitor cell proliferation
by: Elsegood, C., et al.
Published: (2016)

Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture
by: Matthews, V., et al.
Published: (2005)

Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice
by: Knight, B., et al.
Published: (2007)

Jekyll and Hyde: evolving perspectives on the function and potential of the adult liver progenitor (oval) cell
by: Knight, B., et al.
Published: (2005)

The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease
by: Shirolkar, Gayatri Dhananjay
Published: (2021)

Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib
by: Woo, K., et al.
Published: (2016)

Liver Sinusoidal Endothelial Cell (LSEC) isolation following a liver perfusion technique
by: Saharudin, Shahida, et al.
Published: (2017)

Botanic power: for liver and kidney cells regeneration
by: Hazali, Norazlanshah, et al.
Published: (2011)

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications
by: Che Abdullah, Che Azurahanim, et al.
Published: (2014)

Deciphering the role of BMP4 signalling and gene regulation in the specification of human liver progenitor cells
by: Durczak, Paulina Maria
Published: (2023)

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.
by: Matthijssens, Filip, et al.
Published: (2021)

Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma
by: Zhang, A., et al.
Published: (2010)

Wnt/ß-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
by: Shirolkar, Gayatri, et al.
Published: (2018)

Mathematical modelling of cell aggregation in liver tissue engineering
by: Green, John Edward E.
Published: (2006)

Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects
by: Mathavan, S., et al.
Published: (2017)

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury
by: Grzelak, C., et al.
Published: (2014)

Effect of Pluchea Indica on glucose consumption of chang liver cells
by: Suriyah, Wastuti, et al.
Published: (2013)

Antiproliferative effect of gelam honey on liver cancer cell line
by: Zakiah, J, et al.
Published: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7gsi986tjsps6om9p6s7qh3ln7