Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease

Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease

Cystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary cirrhosis; however, its cause(s) and early pathogenesis are unclear. We hypothesized that a bile acid–induced ductular reaction (DR) drives fibrogenesis. The DR was evaluated by cytokeratin-7 immunohistoc...

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Bibliographic Details
Main Authors: Pozniak, K., Pearen, M., Pereira, T., Kramer, C., Kalita-De Croft, P., Nawaratna, S., Fernandez-Rojo, M., Gobert, G., Tirnitz-Parker, Nina, Olynyk, John, Shepherd, R., Lewindon, P., Ramm, G.
Format: Journal Article
Published: Elsevier Inc. 2017
Online Access:http://hdl.handle.net/20.500.11937/59233

Internet

http://hdl.handle.net/20.500.11937/59233

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