Development of a Model for Functional Studies of ABCG2 (Breast Cancer Resistance Protein) Efflux Employing a Standard BeWo Clone (B24)

Development of a Model for Functional Studies of ABCG2 (Breast Cancer Resistance Protein) Efflux Employing a Standard BeWo Clone (B24)

Human choriocarcinoma-derived BeWo cells express high levels of breast cancer resistance protein (BCRP/ABCG2) with no functional P-glycoprotein (P-gp) (ABCB1) activity, making them a potential model to study bidirectional ABCG2-mediated drug transport. However, the original BeWo clone (B24) availabl...

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Bibliographic Details
Main Authors: Crowe, Andrew, Keelan, J.
Format: Journal Article
Published: Mary Ann Liebert 2012
Subjects:
monolayer
TEER
transport
active efflux
cell model
BeWo
BCRP
Online Access:http://hdl.handle.net/20.500.11937/5886

Internet

http://hdl.handle.net/20.500.11937/5886

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