Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink results in a tunable stiffness gradient...

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Bibliographic Details
Main Authors: Hadden, W., Young, J., Holle, A., McFetridge, M., Kim, Du Yong, Wijesinghe, P., Taylor-Weiner, H., Wen, J., Lee, A., Bieback, K., Vo, Ba-Ngu, Sampson, D., Kennedy, B., Spatz, J., Engler, A., Cho, Y.
Format: Journal Article
Published: National Academy of Sciences 2017
Online Access:http://hdl.handle.net/20.500.11937/56114