The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice
Background: Thyroid hormones (TH) regulate cholesterol metabolism but their use as lipid-lowering drugs is restricted due to negative cardiac effects. TH mimetic compounds modulating TH receptor ß (THRß) have been designed as potential drugs, reducing serum cholesterol levels while avoiding apparent...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Public Library of Science
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/55900 |