Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin

A wide variety of drugs bind to human serum albumin (HSA) at its two principal sites, namely site I and site II. A number of reports indicate that drug binding to these two binding sites are not completely independent, and that interactions between ligands of these two discrete sites can play a role...

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Bibliographic Details
Main Authors: Yamasaki, K., Hyodo, S., Taguchi, K., Nishi, K., Yamaotsu, N., Hirono, S., Chuang, Victor, Seo, H., Maruyama, T., Otagiri, M.
Format: Journal Article
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/20.500.11937/54852