GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic ß-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires glucose metabo...

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Bibliographic Details
Main Authors: Carlessi, Rodrigo, Chen, Y., Rowlands, J., Cruzat, Vinicius, Keane, Kevin, Egan, L., Mamotte, Cyril, Stokes, R., Gunton, J., Bittencourt, P., Newsholme, Philip
Format: Journal Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/20.500.11937/54805

Internet

http://hdl.handle.net/20.500.11937/54805

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