Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domain
Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically involves the binding of a Wnt protein to the cysteine-rich domain (CRD) of a Frizzled receptor; Wnt-Frizzled interactions can be antagonized by secreted Frizzled-related prot...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
The American Society for Biochemistry and Molecular Biology Inc
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54450 |