Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women

QR Code

Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women

Background: Previous studies carried out in our laboratories have demonstrated impaired drug permeation in diabetic animals. In this study the permeation of diazepam (after a single dose of 5 mg/day, administered intramuscularly) will be investigated in diabetic and hypertensive pregnant women.Metho...

Full description

Bibliographic Details
Main Authors:	Lalic-Popovic, M., Paunkovic, J., Grujic, Z., Golocorbin-Kon, S., Al-Salami, Hani, Mikov, Momir
Format:	Journal Article
Published:	BioMed Central Ltd 2013
Subjects:	Drug placental-permeation Diazepam Hypertension Diabetes
Online Access:	http://hdl.handle.net/20.500.11937/5412

Similar Items

Decreased placental and transcellular permeation of cefuroxime in pregnant women with diabetes
by: Lalic-Popovic, M., et al.
Published: (2015)

The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine
by: Lalic-Popovic, M., et al.
Published: (2016)

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation
by: Eisele, Nicole, et al.
Published: (2016)

Microstructure control of oxygen permeation membranes with templated microchannels
by: Shao, Xin, et al.
Published: (2014)

Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats
by: Al-Salami, Hani, et al.
Published: (2009)

Effect of hyperglycaemia on VEGF-A splice variants, junctional integrity and vascular leakage in human feto-placental vessels from normal and type 1 diabetic pregnancies
by: Sciota, Flavia
Published: (2012)

Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat
by: Lalic-Popovic, M., et al.
Published: (2013)

Improvement of oxygen permeation through microchanneled ceramic membranes
by: Shao, Xin, et al.
Published: (2014)

Placental expression of adenosine A2A receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system
by: Kurlak, L.O., et al.
Published: (2015)

Strength and permeation properties of slag blended fly ash based geopolymer concrete
by: Deb, Partha, et al.
Published: (2013)

Platelet angiotensin II binding in non-pregnant women and in normotensive pregnant and hypertensive pregnant women
by: Baker, Philip
Published: (1991)

Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia
by: Smith-Jackson, Kate, et al.
Published: (2015)

THE EFFECT OF BILE ACID SALT SODIUM 3ALPHA, 7ALPHA-DIHYDROXY-12-KETO-5BETA-CHOLANATE (MKC) AND PROBIOTIC PRETREATMENT ON GLICLAZIDE PERMEATION IN ILEAL TISSUES FROM HEALTHY AND DIABETIC RATS
by: Mikov, M., et al.
Published: (2014)

Placental haemodynamics: a computational study of maternal blood flow and oxygen transport in the human placenta
by: Blakey, Adam Matthew
Published: (2024)

Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia
by: Ribiero Hentchke, Marta, et al.
Published: (2018)

High performanceBaCe0.8Y0.2O3-a (BCY) hollow fibre membranes for hydrogen permeation
by: Tan, X., et al.
Published: (2014)

Oxygen permeation behavior of La0.6Sr0.4Co0.8Fe0.2O3 hollow fibre membranes with highly concentrated CO2 exposure
by: Tan, X., et al.
Published: (2012)

Buprenorphine exposure in infants of opioid-dependent mothers at birth
by: Bartu, Anne, et al.
Published: (2012)

Analysing the Skin Barrier from Down Under
by: Grice, J., et al.
Published: (2013)

Genetic analysis of beta 2 adrenergic and Dopamine receptor gene polymorphisms in hypertensive subjects at Hospital Seremban, Malaysia
by: Komara, Makanko
Published: (2013)

Impact of CO2 permeation on inter–layers and reservoir caprock sealing efficiency
by: Al Sayah, Ali Farag A
Published: (2025)

Awareness of hypertensive retinopathy among hypertension patient in Selangor / Faris Abdul Kadir @ Lokman
by: Abdul Kadir @ Lokman, Faris
Published: (2015)

Genetic association study of KCNB1 gene with the susceptibility of hypertension related Left Ventricular Hypertrophy (LVH) patients in Malaysia / Hoh Boon Peng and Khalid Yusoff
by: Hoh, Boon Peng, et al.
Published: (2012)

Health Related Quality of Life among Hypertensive Patients Attending Medical and Nephrology Clinics of Serdang Hospital, Selangor
by: Khaw, Wan-Fei.
Published: (2010)

Expression analysis of COMMD5, NPPA, SLC7A1 and AT1R genes among hypertensive Malays
by: Bdair, Ban Waheed Hussein
Published: (2017)

Correlation between in vitro tests for blood brain barrier penetration with in vivo gliclazide penetration
by: Lalic-Popovic, M., et al.
Published: (2013)

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia
by: Mistry, Hiten D., et al.
Published: (2017)

The influence of impurity ions on the permeation and oxygen reduction properties of Ba0.5Sr0.5Co0.8Fe0.2O3-[delta] perovskite
by: Chen, Y., et al.
Published: (2014)

High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect
by: Golocorbin-Kon, S., et al.
Published: (2017)

Lamotrigine and valproate pharmacokinetics interactions in epileptic patients
by: Lalic, M., et al.
Published: (2009)

Placental morphology of pregnant Iraqi women with rheumatic heart disease
by: Al-Assaf, Anwar IS, et al.
Published: (2016)

Stress, demographic and life-style factors of non-academic staff with hypertension in Malaysian Public University
by: Mohamed, Osman Abubakar
Published: (2016)

Association between e-selectin and AMPD-1 gene polymorphisms and essential hypertension in selected Malaysian subjects
by: Nemati, Reza
Published: (2013)

Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rats to the level seen in untreated healthy rats
by: Al-Salami, Hani, et al.
Published: (2008)

Prevalence, awareness, treatment and control of hypertension in Malaysia: A national study of 16,440 subjects.
by: Gyanchand Rampal, Lekhraj Rampal, et al.
Published: (2008)

Application of bile acids in drug formulation and delivery
by: Stojancevic, M., et al.
Published: (2014)

How to screen for non-adherence to antihypertensive therapy
by: Gupta, Pankaj, et al.
Published: (2016)

Hypertensive diseases of pregnancy predict parent-reported difficult temperament in infancy
by: Robinson, M., et al.
Published: (2013)

La0.7Sr0.3FeO3-α perovskite hollow fiber membranes for oxygen permeationand methane conversion
by: Tan, X., et al.
Published: (2012)

Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery
by: Limon, David, et al.
Published: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ujqj8lntdu920m6r02vnam6scb