mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

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mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Nutrient sensing by mechanistic target of rapamycin complex 1 (mTORC1) on lysosomes and late endosomes (LyLEs) regulates cell growth. Many factors stimulate mTORC1 activity, including the production of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] by class I phosphatidylinositol 3-kinases (...

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Bibliographic Details
Main Authors:	Marat, A., Wallroth, A., Lo, W., Müller, R., Norata, G., Falasca, Marco, Schultz, C., Haucke, V.
Format:	Journal Article
Published:	The American Association for the Advancement of Science 2017
Online Access:	http://hdl.handle.net/20.500.11937/54003

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